In particular, viral entry is the first step in the interaction between the virus and the cell that can initiate, maintain, and spread the infection. The early stages of infection with coronavirus are critical events in the course of the viral cycle. The history of CPZ’s discovery and development is described in addition to the review of literature from published studies within the discipline of virology related to CPZ.
This review aims to 1) inform health care professionals and scientists about the history of CPZ use in psychiatry and its potential anti- SARS-CoV-2 activities 2) inform psychiatrists about its potential anti-SARS-CoV-2 activities, and 3) propose a research protocol for investigating the use of CPZ in the treatment of COVID-19 during the potential second wave. Chlorpromazine (CPZ, Largactil ®) is a well-established antipsychotic medication that has recently been proposed to have antiviral activity against SARS-CoV-2. Some drugs used as antiviral medication have neuropsychiatric side effects, and conversely some psychotropic drugs have antiviral properties.
In the context of COVID-19, several aspects of the relations between psychiatry and the pandemic due to the coronavirus have been described. 8Behavioral Sciences Institute (BSI), Al Ain Hospital, SEHA, Al Ain, United Arab EmiratesĬoronavirus disease 2019 (COVID-19) is a severe acute respiratory syndrome (SARS) in humans that is caused by SARS-associated coronavirus type 2 (SARS-CoV-2).7Kings’ College London, Institute of Psychiatry, Psychology, Neuroscience, Department of Psychological Medicine, Centre for Affective Disorders, London, United Kingdom.6Ambulatory Healthcare Services, Al Maqtaa Healthcare Center, Middle Regions Clinics Division, SEHA, Abu Dhabi, United Arab Emirates.5Department of Pharmacology and Therapeutics, College of Medicine and Health Science, United Arab Emirates University, Al Ain, United Arab Emirates.4Department of Biochemistry, College of Medicine and Health Science, United Arab Emirates University, Al Ain, United Arab Emirates.3Department of Medical Microbiology and Immunology, College of Medicine and Health Science, United Arab Emirates University, Al Ain, United Arab Emirates.2Department of Psychiatry and Behavioral Science, College of Medicine and Health Science, United Arab Emirates University, Al Ain, United Arab Emirates.1Department of Psychiatry, University of Montréal, Montréal, QC, Canada.
Rizvi 3, Farah Mustafa 4, Syed Javaid 2, Salahdein Aburuz 5, Nahida Nayaz Ahmed 6, Karim Abdel Aziz 2, Danilo Arnone 2,7, Aravinthan Subbarayan 8, Fadwa Al Mugaddam 1 and Gulfaraz Khan 3
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